Background: Epiploic appendagitis is a rare non-specificdisease that can be confused with other diseases. Symptoms usually resolve within 2 weeks and obesity and heavy exercise are risk factors for the development of this disease. Case report: A 15-year-old boy who had been previously diagnosed with irritable bowel syndrome(diarrhea type) visited the emergency room(ER) complaining of acute-onset abdominal pain lasting for 1 day, which remained localized in the right lower quadrant (RLQ). He had intermittent fever and watery diarrhea.The body mass index (BMI) of the patient was 31 kg/m2.Examination of the abdomen showed tenderness and rebound tenderness in the RLQ. Laboratory study findings were unremarkable, except for increased alanine aminotransferase. Because of RLQ tenderness, a computed tomography (CT) scan was obtained, which demonstrated a 2.2-cm low attenuating lesion abutting the ascending colon with pericolicfat stranding and diffuse fatty infiltration in the liver without focallesions. Because of the persistent RLQ pain and tenderness, follow-up CT was performed and it showed a decreased lesion without complications. Conclusion: This indicates that epiploic appendagitis may be associated with chronic pain, althoughthis association is very rare.